Eukaryotic gene regulation
نویسندگان
چکیده
منابع مشابه
Bioinformatics of Eukaryotic Gene Regulation
Understanding the mechanisms which control gene expression is one of the fundamental problems of molecular biology. Detailed experimental studies of regulation are laborious due to the complex and combinatorial nature of interactions among involved molecules. Therefore, computational techniques are used to suggest candidate mechanisms for further investigation. This thesis presents three method...
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Recent structure determinations of high order complexes of eukaryotic transcription factors bound to DNA have revealed that residues from their DNA-binding domains are involved in protein-protein interactions between distinct factors. Protein-protein interactions between transactivation domains and coactivators have also been characterized in a number of recently determined structures. These st...
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The regulation of transcriptional elongation and termination is well documented as a means of controlling the expression of prokaryotic genes, and molecular and genetic analysis has yielded a clear understanding of the diverse mechanisms involved (reviewed in Yanofsky, 1988; Spencer and Groudine, 1990; Kerppola and Kane, 1991). It is now evident that the expression of several eukaryotic viral a...
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The chromatin structure around the 5' end of the yeast regulatory gene GAL80 has been determined. The chromatin organization is very similar to that on the 5' regions of the GAL1-10 structural genes: a constitutive hypersensitive region containing the upstream activating sequence (UAS) element, and nucleosomes around this hypersensitive region. The downstream nucleosome, which is a positioned n...
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Regulation of genes is fundamental to all living processes and can be exerted at many sequential steps. We studied several eukaryotic gene regulatory mechanisms with an emphasis on understanding the interplay between regulatory processes on a genome-wide scale. Gene splicing involves the joining of exonic RNA stretches from within a precursor messenger RNA (mRNA). Splicing typically occurs co-t...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2000
ISSN: 1074-5521
DOI: 10.1016/s1074-5521(00)00071-5